Pharmacokinetics and sputum penetration of ciprofloxacin in patients with cystic fibrosis.
نویسندگان
چکیده
Levels of ciprofloxacin in serum and sputum were studied for eight patients with cystic fibrosis who were infected with Pseudomonas aeruginosa. Patients were studied in a steady state on a dosage of 500 mg every 8 h. Peak levels in serum ranged from 1.27 to 5.6 mg/liter (mean, 3.16 +/- 1.27), and absorption was rapid, the time to peak concentration ranging from 0.5 to 3.0 h (mean, 1.5 +/- 0.9). The antibiotic penetrated sputum well, achieving areas under the curve of approximately 46% of those obtained in serum.
منابع مشابه
Pharmacokinetics and pharmacodynamics of ciprofloxacin in cystic fibrosis patients.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 30 4 شماره
صفحات -
تاریخ انتشار 1986